COSA score online calculator

Covid-19 severity assessment prognostic risk score

Description

Predict likelihood of severe clinical outcomes (death of any cause / need for intensive care) in patients with positive SARS-CoV-2 PCR. Link to the original publication (Schöning et al., J Transl Med 19, 56 (2021)) and to the revalidation for the 3rd and 4th waves.

Usage

The score predicts individual likelihood for severe outcomes based on laboratory values taken three days prior to and up to one day after first positive SARS-CoV-2 PCR result.
If more than one measurement is available from this period, choose the most extreme values:
- maximum C-reactive protein (CRP), sodium, glucose, leucocytes, and
- minimum hemoglobin, and estimated glomerular filtration rate (eGFR CKD-EPI).

Parameter

Value

Units

Cut-off

Scoring

Male sex

check if yes

Male sex

1 point

CRP (max)

mg/L

≥ 25 mg/L

3 points

Leucocytes (max)

G/L

≥ 10 G/L

2 points

Sodium (max)

mmol/L

≥ 144 mmol/L

1 point

Glucose (max)

mmol/L

≥ 8.6 mmol/L

1 point

Hemoglobin (min)

g/L

≤ 100 g/L

1 point

eGFR (CKD-EPI, min)

mL/min

≤ 75 mL/min

1 point

Score: 0

Total score per patient

0-3 points: low risk for severe COVID-19 (<5%)

4-5 points: moderate risk for severe COVID-19 (<50%)

6-7 points: high risk for severe COVID-19 (>50%)

8-10 points: very high risk for severe COVID-19 (>90%)